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Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Generic Sinemet can be taken with or without food. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times.
Mechanism of action. Levodopa is converted to dopamine via the action of a naturally occurring enzyme called DOPA decarboxylase. This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier.

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