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Digoxin side effects. Get emergency medical help if you have signs of an allergic reaction to digoxin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Possible side effect. Common side effects include nausea, vomiting, headache, dizziness, skin rash, and mental changes, blurred vision, hives, difficulty breathing; swelling of your face, lips, uneven heart rate, hallucinations, diarrhea. Get emergency medical help if you have any unusual or bothersome side effect.
Digoxin, if it is effective, has some unique advantages compared with the existing heart failure medications. Provided toxicity is avoided, digoxin is remarkably free of side effects. Unlike other interventions for heart failure, except cardiac resynchronisation therapy,8 digoxin increases systolic blood pressure. It is extracted from the leaves of a plant called digitalis lanata. Digoxin increases the force of contraction of the muscle of the heart by inhibiting the activity of an enzyme (ATPase) that controls movement of calcium, sodium, and potassium into heart muscle. Calcium controls the force of contraction.
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Digoxin is used to treat congestive heart failure, usually in combination with a diuretic (water pill) and an angiotensin-converting enzyme (ACE) inhibitor. It is also used to treat a heart rhythm problem called atrial fibrillation. Digoxin belongs to the class of medicines called digitalis glycosides.
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